CD103(+) regulatory T cells underlie resistance to radio-immunotherapy and impair CD8(+) T cell activation in glioblastoma

Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-centric immunotherapy due to their low mutational burden and immunosuppressive tumor microenvironment. Here we report that fractionated radiotherapy of preclinical glioblastoma models induce a tenfold increase in...

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Detalles Bibliográficos
Autores principales: van Hooren, Luuk, Handgraaf, Shanna M., Kloosterman, Daan J., Karimi, Elham, van Mil, Lotte W.H.G., Gassama, Awa A., Solsona, Beatriz Gomez, de Groot, Marnix H. P., Brandsma, Dieta, Quail, Daniela F., Walsh, Logan A., Borst, Gerben R., Akkari, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212765/
https://www.ncbi.nlm.nih.gov/pubmed/37081259
http://dx.doi.org/10.1038/s43018-023-00547-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212765/
https://www.ncbi.nlm.nih.gov/pubmed/37081259
http://dx.doi.org/10.1038/s43018-023-00547-6

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