A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders

Mutations in activin receptor-like kinase 2 (ALK2) can cause the pathological osteogenic signaling seen in some patients with fibrodysplasia ossificans progressiva and other conditions such as diffuse intrinsic pontine glioma. Here, we report that intracellular domain of wild-type ALK2 readily dimer...

Descripción completa

Detalles Bibliográficos
Autores principales: Katagiri, Takenobu, Tsukamoto, Sho, Kuratani, Mai, Tsuji, Shinnosuke, Nakamura, Kensuke, Ohte, Satoshi, Kawaguchi, Yoshiro, Takaishi, Kiyosumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212922/
https://www.ncbi.nlm.nih.gov/pubmed/37231012
http://dx.doi.org/10.1038/s41467-023-38746-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212922/
https://www.ncbi.nlm.nih.gov/pubmed/37231012
http://dx.doi.org/10.1038/s41467-023-38746-5

Ejemplares similares