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A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders
Mutations in activin receptor-like kinase 2 (ALK2) can cause the pathological osteogenic signaling seen in some patients with fibrodysplasia ossificans progressiva and other conditions such as diffuse intrinsic pontine glioma. Here, we report that intracellular domain of wild-type ALK2 readily dimer...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212922/ https://www.ncbi.nlm.nih.gov/pubmed/37231012 http://dx.doi.org/10.1038/s41467-023-38746-5 |