Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism

Although more adeno-associated virus AAV-based drugs enter the clinic, vector tissue tropism remains an unresolved challenge that limits its full potential despite that the tissue tropism of naturally occurring AAV serotypes can be altered by genetic engineering capsid vie DNA shuffling, or molecula...

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Detalles Bibliográficos
Autores principales: Mulcrone, Patrick L., Lam, Anh K., Frabutt, Dylan, Zhang, Junping, Chrzanowski, Matthew, Herzog, Roland W., Xiao, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212940/
https://www.ncbi.nlm.nih.gov/pubmed/37231038
http://dx.doi.org/10.1038/s41598-023-35547-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212940/
https://www.ncbi.nlm.nih.gov/pubmed/37231038
http://dx.doi.org/10.1038/s41598-023-35547-0

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