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Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism
Although more adeno-associated virus AAV-based drugs enter the clinic, vector tissue tropism remains an unresolved challenge that limits its full potential despite that the tissue tropism of naturally occurring AAV serotypes can be altered by genetic engineering capsid vie DNA shuffling, or molecula...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212940/ https://www.ncbi.nlm.nih.gov/pubmed/37231038 http://dx.doi.org/10.1038/s41598-023-35547-0 |