New drug-like small molecule antagonizes phosphatidylinositol (3,4,5)-trisphosphate (PIP3) in patients with conotruncal heart defects

OBJECTIVES: Conotruncal heart defects (CTDs) are highly heritable, and approximately one-third of all congenital heart defects are due to CTDs. Through post-analysis of GWAS data relevant to CTDs, a new putative signal transduction pathway, called Vars2-Pic3ca-Akt, associated with CTD has been hypot...

Descripción completa

Detalles Bibliográficos
Autores principales: Fayez, Alaaeldin G., Esmaiel, Nora N., Ashaat, Engy A., Refeat, Miral M., Lotfy, Randa S., Raouf, Haiam Abdel, El Ruby, Mona O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taibah University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213100/
https://www.ncbi.nlm.nih.gov/pubmed/37250809
http://dx.doi.org/10.1016/j.jtumed.2023.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213100/
https://www.ncbi.nlm.nih.gov/pubmed/37250809
http://dx.doi.org/10.1016/j.jtumed.2023.04.006

Ejemplares similares