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New drug-like small molecule antagonizes phosphatidylinositol (3,4,5)-trisphosphate (PIP3) in patients with conotruncal heart defects

OBJECTIVES: Conotruncal heart defects (CTDs) are highly heritable, and approximately one-third of all congenital heart defects are due to CTDs. Through post-analysis of GWAS data relevant to CTDs, a new putative signal transduction pathway, called Vars2-Pic3ca-Akt, associated with CTD has been hypot...

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Detalles Bibliográficos
Autores principales:	Fayez, Alaaeldin G., Esmaiel, Nora N., Ashaat, Engy A., Refeat, Miral M., Lotfy, Randa S., Raouf, Haiam Abdel, El Ruby, Mona O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taibah University 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213100/ https://www.ncbi.nlm.nih.gov/pubmed/37250809 http://dx.doi.org/10.1016/j.jtumed.2023.04.006

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