Intranasal 15d-PGJ2 inhibits the growth of rat lactotroph pituitary neuroendocrine tumors by inducing PPARγ-dependent apoptotic and autophagic cell death

PPARγ agonists have been reported to induce cell death in pituitary neuroendocrine tumor (PitNET) cell cultures. However, the therapeutic effects of PPARγ agonists in vivo remain unclear. In the present study, we found that intranasal 15d-PGJ2, an endogenous PPARγ agonist, resulted in growth suppres...

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Detalles Bibliográficos
Autores principales: Li, Zongyang, Chen, Lei, Zhang, Di, Huang, Xianjian, Yang, Jihu, Li, Weiping, Wang, Chuanfang, Meng, Xiangbao, Huang, Guodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213263/
https://www.ncbi.nlm.nih.gov/pubmed/37250410
http://dx.doi.org/10.3389/fnins.2023.1109675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213263/
https://www.ncbi.nlm.nih.gov/pubmed/37250410
http://dx.doi.org/10.3389/fnins.2023.1109675

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