Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Adoptive cell therapy based on chimeric antigen receptor (CAR)-engineered T-cells has proven to be lifesaving for many cancer patients. However, its therapeutic efficacy has so far been restricted to only a few malignancies, with solid tumors proving to be especially recalcitrant to efficient therap...

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Detalles Bibliográficos
Autores principales: Das, Shipra, Valton, Julien, Duchateau, Philippe, Poirot, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213512/
https://www.ncbi.nlm.nih.gov/pubmed/37251405
http://dx.doi.org/10.3389/fimmu.2023.1172681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213512/
https://www.ncbi.nlm.nih.gov/pubmed/37251405
http://dx.doi.org/10.3389/fimmu.2023.1172681

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