PPRX-1701, a nanoparticle formulation of 6′-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models

Derivatives of the Chinese traditional medicine indirubin have shown potential for the treatment of cancer through a range of mechanisms. This study investigates the impact of 6′-bromoindirubin-3′-acetoxime (BiA) on immunosuppressive mechanisms in glioblastoma (GBM) and evaluates the efficacy of a B...

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Detalles Bibliográficos
Autores principales: Zdioruk, Mykola, Jimenez-Macias, Jorge-Luis, Nowicki, Michal Oskar, Manz, Katherine E., Pennell, Kurt D., Koch, Marilin S., Finkelberg, Tomer, Wu, Bin, Boucher, Paul, Takeda, Yuji, Li, Weiyi, Piranlioglu, Raziye, Ling, Alexander L., Chiocca, E. Antonio, Lawler, Sean E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213750/
https://www.ncbi.nlm.nih.gov/pubmed/37060903
http://dx.doi.org/10.1016/j.xcrm.2023.101019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213750/
https://www.ncbi.nlm.nih.gov/pubmed/37060903
http://dx.doi.org/10.1016/j.xcrm.2023.101019

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