8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weigh...

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Detalles Bibliográficos
Autores principales: Knez, Damijan, Diez-Iriepa, Daniel, Chioua, Mourad, Gottinger, Andrea, Denic, Milica, Chantegreil, Fabien, Nachon, Florian, Brazzolotto, Xavier, Skrzypczak-Wiercioch, Anna, Meden, Anže, Pišlar, Anja, Kos, Janko, Žakelj, Simon, Stojan, Jure, Sałat, Kinga, Serrano, Julia, Fernández, Ana Patricia, Sánchez-García, Aitana, Martínez-Murillo, Ricardo, Binda, Claudia, López-Muñoz, Francisco, Gobec, Stanislav, Marco-Contelles, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213797/
https://www.ncbi.nlm.nih.gov/pubmed/37250172
http://dx.doi.org/10.1016/j.apsb.2023.01.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213797/
https://www.ncbi.nlm.nih.gov/pubmed/37250172
http://dx.doi.org/10.1016/j.apsb.2023.01.013

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