Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling

Inflammation, abnormal cholesterol metabolism, and macrophage infiltration are involved in the destruction of the extracellular matrix of the nucleus pulposus (NP), culminating in intervertebral disc degeneration (IDD). Whether nimbolide (Nim), a natural extract, can alleviate IDD is unclear. In thi...

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Detalles Bibliográficos
Autores principales: Teng, Yun, Huang, Yixue, Yu, Hao, Wu, Cenhao, Yan, Qi, Wang, Yingjie, Yang, Ming, Xie, Haifeng, Wu, Tianyi, Yang, Huilin, Zou, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213799/
https://www.ncbi.nlm.nih.gov/pubmed/37250166
http://dx.doi.org/10.1016/j.apsb.2023.02.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213799/
https://www.ncbi.nlm.nih.gov/pubmed/37250166
http://dx.doi.org/10.1016/j.apsb.2023.02.018

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