Large-scale functional screen identifies genetic variants with splicing effects in modern and archaic humans

Humans coexisted and interbred with other hominins which later became extinct. These archaic hominins are known to us only through fossil records and for two cases, genome sequences. Here, we engineer Neanderthal and Denisovan sequences into thousands of artificial genes to reconstruct the pre-mRNA...

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Detalles Bibliográficos
Autores principales: Rong, Stephen, Neil, Christopher R., Welch, Anastasia, Duan, Chaorui, Maguire, Samantha, Meremikwu, Ijeoma C., Meyerson, Malcolm, Evans, Ben J., Fairbrother, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214146/
https://www.ncbi.nlm.nih.gov/pubmed/37192163
http://dx.doi.org/10.1073/pnas.2218308120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214146/
https://www.ncbi.nlm.nih.gov/pubmed/37192163
http://dx.doi.org/10.1073/pnas.2218308120

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