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A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation
Animal opsins, light-sensitive G protein-coupled receptors, have been used for optogenetic tools to control G protein-dependent signaling pathways. Upon G protein activation, the Gα and Gβγ subunits drive different intracellular signaling pathways, leading to complex cellular responses. For some pur...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214182/ https://www.ncbi.nlm.nih.gov/pubmed/37186850 http://dx.doi.org/10.1073/pnas.2301269120 |