PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress

Molecular classification of gastric cancer (GC) identified a subgroup of patients showing chemoresistance and poor prognosis, termed SEM (Stem-like/Epithelial-to-mesenchymal transition/Mesenchymal) type in this study. Here, we show that SEM-type GC exhibits a distinct metabolic profile characterized...

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Detalles Bibliográficos
Autores principales: Yoon, Bo Kyung, Kim, Hyeonhui, Oh, Tae Gyu, Oh, Se Kyu, Jo, Sugyeong, Kim, Minki, Chun, Kyu-Hye, Hwang, Nahee, Lee, Suji, Jin, Suyon, Atkins, Annette R., Yu, Ruth T., Downes, Michael, Kim, Jae-woo, Kim, Hyunkyung, Evans, Ronald M., Cheong, Jae-Ho, Fang, Sungsoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214193/
https://www.ncbi.nlm.nih.gov/pubmed/37192160
http://dx.doi.org/10.1073/pnas.2217826120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214193/
https://www.ncbi.nlm.nih.gov/pubmed/37192160
http://dx.doi.org/10.1073/pnas.2217826120

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