Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains

Neurodegenerative diseases, such as Alzheimer’s disease (AD), are associated with protein misfolding and aggregation into amyloid fibrils. Increasing evidence suggests that soluble, low-molecular-weight aggregates play a key role in disease-associated toxicity. Within this population of aggregates,...

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Detalles Bibliográficos
Autores principales: Miller, Alyssa, Wei, Jiapeng, Meehan, Sarah, Dobson, Christopher M., Welland, Mark E., Klenerman, David, Vendruscolo, Michele, Ruggeri, Francesco Simone, Knowles, Tuomas P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214208/
https://www.ncbi.nlm.nih.gov/pubmed/37186840
http://dx.doi.org/10.1073/pnas.2216234120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214208/
https://www.ncbi.nlm.nih.gov/pubmed/37186840
http://dx.doi.org/10.1073/pnas.2216234120

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