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Proofreading does not result in more reliable ligand discrimination in receptor signaling due to its inherent stochasticity
Kinetic proofreading (KPR) has been used as a paradigmatic explanation for the high specificity of ligand discrimination by cellular receptors. KPR enhances the difference in the mean receptor occupancy between different ligands compared to a nonproofread receptor, thus potentially enabling better d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214210/ https://www.ncbi.nlm.nih.gov/pubmed/37192165 http://dx.doi.org/10.1073/pnas.2212795120 |