Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-β42 aggregation and fibril formation

The chaperone Hsp104, a member of the Hsp100/Clp family of translocases, prevents fibril formation of a variety of amyloidogenic peptides in a paradoxically substoichiometric manner. To understand the mechanism whereby Hsp104 inhibits fibril formation, we probed the interaction of Hsp104 with the Al...

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Detalles Bibliográficos
Autores principales: Ghosh, Shreya, Tugarinov, Vitali, Clore, G. Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214214/
https://www.ncbi.nlm.nih.gov/pubmed/37186848
http://dx.doi.org/10.1073/pnas.2305823120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214214/
https://www.ncbi.nlm.nih.gov/pubmed/37186848
http://dx.doi.org/10.1073/pnas.2305823120

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