Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis

Cell reprogramming to a myofibroblast responsible for the pathological accumulation of extracellular matrix is fundamental to the onset of fibrosis. Here, we explored how condensed chromatin structure marked by H3K72me3 becomes modified to allow for activation of repressed genes to drive emergence o...

Descripción completa

Detalles Bibliográficos
Autores principales: Basta, Morgan D., Petruk, Svetlana, Summer, Ross, Rosenbloom, Joel, Wermuth, Peter J., Macarak, Edward, Levin, Alex V., Mazo, Alexander, Walker, Janice L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214303/
https://www.ncbi.nlm.nih.gov/pubmed/37250334
http://dx.doi.org/10.1016/j.isci.2023.106570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214303/
https://www.ncbi.nlm.nih.gov/pubmed/37250334
http://dx.doi.org/10.1016/j.isci.2023.106570

Ejemplares similares