C9ORF72 suppresses JAK-STAT mediated inflammation

Hexanucleotide repeat expansion in the gene C9ORF72 is a leading cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). C9ORF72 deficiency leads to severe inflammatory phenotypes in mice, but exactly how C9ORF72 regulates inflammation remains to be fully elucidate...

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Detalles Bibliográficos
Autores principales: Pang, Weilun, Hu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214391/
https://www.ncbi.nlm.nih.gov/pubmed/37250330
http://dx.doi.org/10.1016/j.isci.2023.106579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214391/
https://www.ncbi.nlm.nih.gov/pubmed/37250330
http://dx.doi.org/10.1016/j.isci.2023.106579

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