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Neutralization of Intracellular pH Homeostasis to Inhibit Osteoclasts Based on a Spatiotemporally Selective Delivery System

[Image: see text] Osteoporosis is a global disease caused by abnormal overactivation of osteoclasts. The acidic environment in sealing zone of osteoclasts with H(+) pumped from cytoplasm is critical to the maturation of osteoclasts. Therefore, reducing the intracellular H(+) concentration can reduce...

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Detalles Bibliográficos
Autores principales: Tian, Hongsen, Gu, Chenhui, Li, Wenshuai, Tong, Tong, Wang, Yunsheng, Yang, Yang, Wang, Haoli, Dai, Zhanqiu, Chen, Pengfei, Wang, Feng, Lin, Xianfeng, Shangguan, Liqing, Wang, Linfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214447/
https://www.ncbi.nlm.nih.gov/pubmed/37183806
http://dx.doi.org/10.1021/acs.nanolett.2c04295