A gut microbiome metabolite paradoxically depresses contractile function while activating mitochondrial respiration

Trimethylamine-N-oxide (TMAO) is an end-product of gut microbiome metabolism linked to cardiovascular disease (CVD). However, precise cardiovascular influences of the TMAO concentrations reported in early or severe disease remain to be detailed. We investigated acute effects of TMAO on cardiac contr...

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Detalles Bibliográficos
Autores principales: Naghipour, Saba, Fisher, Joshua J., Perkins, Anthony V., Peart, Jason N., Headrick, John P., Toit, Eugene F. Du
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214852/
https://www.ncbi.nlm.nih.gov/pubmed/37078591
http://dx.doi.org/10.1242/dmm.049975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214852/
https://www.ncbi.nlm.nih.gov/pubmed/37078591
http://dx.doi.org/10.1242/dmm.049975

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