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APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA 5′-end, which arises from abortive ligat...
Autores principales: | Imamura, Rikiya, Saito, Mizuki, Shimada, Mikio, Kobayashi, Junya, Ishiai, Masamichi, Matsumoto, Yoshihisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214999/ https://www.ncbi.nlm.nih.gov/pubmed/36940705 http://dx.doi.org/10.1093/jrr/rrad007 |
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