Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2

As immunological selection for escape mutants continues to give rise to future SARS-CoV-2 variants, novel universal therapeutic strategies against ACE2-dependent viruses are needed. Here we present an IgM-based decavalent ACE2 decoy that has variant-agnostic efficacy. In immuno-, pseudovirus, and li...

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Detalles Bibliográficos
Autores principales: Verstraete, Meghan M., Heinkel, Florian, Li, Janessa, Cao, Siran, Tran, Anh, Halverson, Elizabeth C., Gene, Robert, Stangle, Elizabeth, Silva-Moreno, Begonia, Arrafi, Sifa, Bavananthasivam, Jegarubee, Fung, Madeline, Eji-Lasisi, Mariam, Masterman, Stephanie, Xanthoudakis, Steve, Dixit, Surjit, Babcook, John, Clavette, Brandon, Fogg, Mark, Escobar-Cabrera, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215022/
https://www.ncbi.nlm.nih.gov/pubmed/37229608
http://dx.doi.org/10.1080/19420862.2023.2212415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215022/
https://www.ncbi.nlm.nih.gov/pubmed/37229608
http://dx.doi.org/10.1080/19420862.2023.2212415

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