Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity

In a previous study published by our group, successful modification of the antibiotic chloramphenicol (CHL) was reported, which was achieved by replacing the dichloroacetyl tail with alpha and beta amino acids, resulting in promising new antibacterial pharmacophores. In this study, CHL was further m...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsirogianni, Artemis, Kournoutou, Georgia G., Mpogiatzoglou, Maria, Dinos, George, Athanassopoulos, Constantinos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215083/
https://www.ncbi.nlm.nih.gov/pubmed/37237735
http://dx.doi.org/10.3390/antibiotics12050832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215083/
https://www.ncbi.nlm.nih.gov/pubmed/37237735
http://dx.doi.org/10.3390/antibiotics12050832

Ejemplares similares