The Fate of Oxidative Strand Breaks in Mitochondrial DNA

Mitochondrial DNA (mtDNA) is particularly vulnerable to somatic mutagenesis. Potential mechanisms include DNA polymerase γ (POLG) errors and the effects of mutagens, such as reactive oxygen species. Here, we studied the effects of transient hydrogen peroxide (H(2)O(2) pulse) on mtDNA integrity in cu...

Descripción completa

Detalles Bibliográficos
Autores principales: Trombly, Genevieve, Said, Afaf Milad, Kudin, Alexei P., Peeva, Viktoriya, Altmüller, Janine, Becker, Kerstin, Köhrer, Karl, Zsurka, Gábor, Kunz, Wolfram S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215735/
https://www.ncbi.nlm.nih.gov/pubmed/37237953
http://dx.doi.org/10.3390/antiox12051087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215735/
https://www.ncbi.nlm.nih.gov/pubmed/37237953
http://dx.doi.org/10.3390/antiox12051087

Ejemplares similares