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The Fate of Oxidative Strand Breaks in Mitochondrial DNA

Mitochondrial DNA (mtDNA) is particularly vulnerable to somatic mutagenesis. Potential mechanisms include DNA polymerase γ (POLG) errors and the effects of mutagens, such as reactive oxygen species. Here, we studied the effects of transient hydrogen peroxide (H(2)O(2) pulse) on mtDNA integrity in cu...

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Detalles Bibliográficos
Autores principales:	Trombly, Genevieve, Said, Afaf Milad, Kudin, Alexei P., Peeva, Viktoriya, Altmüller, Janine, Becker, Kerstin, Köhrer, Karl, Zsurka, Gábor, Kunz, Wolfram S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215735/ https://www.ncbi.nlm.nih.gov/pubmed/37237953 http://dx.doi.org/10.3390/antiox12051087

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