Exploring Alternative Pathways to Target Bacterial Type II Topoisomerases Using NBTI Antibacterials: Beyond Halogen-Bonding Interactions

Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of antibacterial agents that target bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). Our recently disclosed crystal structure of an NBTI ligand in complex with DNA gyrase and DNA revealed that the halogen atom in the...

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Detalles Bibliográficos
Autores principales: Kokot, Maja, Novak, Doroteja, Zdovc, Irena, Anderluh, Marko, Hrast, Martina, Minovski, Nikola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215804/
https://www.ncbi.nlm.nih.gov/pubmed/37237833
http://dx.doi.org/10.3390/antibiotics12050930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215804/
https://www.ncbi.nlm.nih.gov/pubmed/37237833
http://dx.doi.org/10.3390/antibiotics12050930

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