Pre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution

This study compares the effects of pre-processing multiple polymers together to form a single-phase polymer alloy prior to amorphous solid dispersion formulation. KinetiSol compounding was used to pre-process a 1:1 (w/w) ratio of hypromellose acetate succinate and povidone to form a single-phase pol...

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Detalles Bibliográficos
Autores principales: Thompson, Stephen A., Davis, Daniel A., Miller, Dave A., Kucera, Sandra U., Williams, Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215938/
https://www.ncbi.nlm.nih.gov/pubmed/37238952
http://dx.doi.org/10.3390/biomedicines11051281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215938/
https://www.ncbi.nlm.nih.gov/pubmed/37238952
http://dx.doi.org/10.3390/biomedicines11051281

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