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Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson’s Disease
Leucine-rich repeat kinase 2 (LRRK2) is a large protein kinase that physiologically phosphorylates and regulates the function of several Rab proteins. LRRK2 is genetically implicated in the pathogenesis of both familial and sporadic Parkinson’s disease (PD), although the underlying mechanism is not...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216118/ https://www.ncbi.nlm.nih.gov/pubmed/37238714 http://dx.doi.org/10.3390/biom13050845 |