Anionic Phospholipids Shift the Conformational Equilibrium of the Selectivity Filter in the KcsA Channel to the Conductive Conformation: Predicted Consequences on Inactivation

Here, we report an allosteric effect of an anionic phospholipid on a model K(+) channel, KcsA. The anionic lipid in mixed detergent–lipid micelles specifically induces a change in the conformational equilibrium of the channel selectivity filter (SF) only when the channel inner gate is in the open st...

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Detalles Bibliográficos
Autores principales: Renart, María Lourdes, Giudici, Ana Marcela, Coll-Díez, Carlos, González-Ros, José M., Poveda, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216125/
https://www.ncbi.nlm.nih.gov/pubmed/37239046
http://dx.doi.org/10.3390/biomedicines11051376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216125/
https://www.ncbi.nlm.nih.gov/pubmed/37239046
http://dx.doi.org/10.3390/biomedicines11051376

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