Characterization of Stimulatory Action on Voltage-Gated Na(+) Currents Caused by Omecamtiv Mecarbil, Known to Be a Myosin Activator

Omecamtiv mecarbil (OM, CK-1827452) is recognized as an activator of myosin and has been demonstrated to be beneficial for the treatment of systolic heart failure. However, the mechanisms by which this compound interacts with ionic currents in electrically excitable cells remain largely unknown. The...

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Detalles Bibliográficos
Autores principales: Ting, Chih-Yu, Shih, Chia-Lung, Yu, Meng-Cheng, Wu, Chao-Liang, Wu, Sheng-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216194/
https://www.ncbi.nlm.nih.gov/pubmed/37239022
http://dx.doi.org/10.3390/biomedicines11051351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216194/
https://www.ncbi.nlm.nih.gov/pubmed/37239022
http://dx.doi.org/10.3390/biomedicines11051351

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