Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities

The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives. We previously described the excellent in vitro activity of a novel pyrrolizidinylmethyl derivative of 4-a...

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Detalles Bibliográficos
Autores principales: Basilico, Nicoletta, Parapini, Silvia, D’Alessandro, Sarah, Misiano, Paola, Romeo, Sergio, Dondio, Giulio, Yardley, Vanessa, Vivas, Livia, Nasser, Shereen, Rénia, Laurent, Russell, Bruce M., Suwanarusk, Rossarin, Nosten, François, Sparatore, Anna, Taramelli, Donatella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216263/
https://www.ncbi.nlm.nih.gov/pubmed/37238706
http://dx.doi.org/10.3390/biom13050836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216263/
https://www.ncbi.nlm.nih.gov/pubmed/37238706
http://dx.doi.org/10.3390/biom13050836

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