The Interaction of Factor Xa and IXa with Non-Activated Antithrombin in Michaelis Complex: Insights from Enhanced-Sampling Molecular Dynamics Simulations

The interaction between coagulation factors Xa and IXa and the activated state of their inhibitor, antithrombin (AT),have been investigated using X-ray diffraction studies. However, only mutagenesis data are available for non-activated AT. Our aim was to propose a model based on docking and advanced...

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Detalles Bibliográficos
Autores principales: Balogh, Gábor, Bereczky, Zsuzsanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216295/
https://www.ncbi.nlm.nih.gov/pubmed/37238665
http://dx.doi.org/10.3390/biom13050795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216295/
https://www.ncbi.nlm.nih.gov/pubmed/37238665
http://dx.doi.org/10.3390/biom13050795

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