Cargando…

STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases

Background: Some neurodegenerative diseases have an element of neuroinflammation that is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the cGAS-STING pathway, microbial and host-derived DNA bind and activate the DNA sensor cGAS, and the resulting cyclic dinu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferecskó, Alex S., Smallwood, Miranda J., Moore, Adrian, Liddle, Corin, Newcombe, Jia, Holley, Janet, Whatmore, Jacqueline, Gutowski, Nicholas J., Eggleton, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216406/ https://www.ncbi.nlm.nih.gov/pubmed/37239045 http://dx.doi.org/10.3390/biomedicines11051375

Ejemplares similares

The Complexity of the cGAS-STING Pathway in CNS Pathologies
por: Fryer, Amelia L., et al.
Publicado: (2021)

CNS Ageing in Health and Neurodegenerative Disorders
por: Kesidou, Evangelia, et al.
Publicado: (2023)

Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium
por: Rai, Srijana, et al.
Publicado: (2015)

TREM2 in CNS homeostasis and neurodegenerative disease
por: Painter, Meghan M., et al.
Publicado: (2015)

CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases
por: Goldsteins, Gundars, et al.
Publicado: (2022)

Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis
por: Hu, Xinli, et al.
Publicado: (2022)

The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer
por: Pranjol, Md Zahidul Islam, et al.
Publicado: (2015)

Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells
por: Abdullah, Trefa M., et al.
Publicado: (2021)

HSV Replication: Triggering and Repressing STING Functionality
por: Krawczyk, Eric, et al.
Publicado: (2023)

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis
por: Haile, Yohannes, et al.
Publicado: (2017)

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?
por: Rezai-Zadeh, Kavon, et al.
Publicado: (2009)

Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy
por: Varga, Kornél Z., et al.
Publicado: (2023)

cGAS-STING triggers inflammaging-associated neurodegeneration
por: Izquierdo, José M.
Publicado: (2023)

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
por: Reinert, Line S., et al.
Publicado: (2016)

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
por: McCoy, Melissa K, et al.
Publicado: (2008)

The Diverse Roles of Microglia in the Neurodegenerative Aspects of Central Nervous System (CNS) Autoimmunity
por: Thompson, Kaitlyn K., et al.
Publicado: (2017)

P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases
por: Illes, Peter
Publicado: (2020)

Novel CSF Biomarkers Tracking Autoimmune Inflammatory and Neurodegenerative Aspects of CNS Diseases
por: Kapaki, Elisabeth, et al.
Publicado: (2022)

Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
por: Noori, Leila, et al.
Publicado: (2023)

Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery
por: LaBarbera, Kelsie Mozzoni, et al.
Publicado: (2021)

Aberrant oligodendroglial-vascular interactions disrupt the Blood Brain Barrier triggering CNS inflammation
por: Niu, Jianqin, et al.
Publicado: (2019)

ROP16 of Toxoplasma gondii Inhibits Innate Immunity by Triggering cGAS-STING Pathway Inactivity through the Polyubiquitination of STING
por: Jin, Qi-Wang, et al.
Publicado: (2023)

Activated STING: an ion channel to trigger non-interferon-related functions
por: Gao, Zhengyu, et al.
Publicado: (2023)

cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
por: Schmitz, Carine Raquel Richter, et al.
Publicado: (2023)

Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma()()
por: Winiarski, Boleslaw K., et al.
Publicado: (2014)

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
por: Holm, Christian K, et al.
Publicado: (2012)

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders
por: Brzdak, Patrycja, et al.
Publicado: (2017)

Resident Memory-like CD8(+) T Cells Are Involved in Chronic Inflammatory and Neurodegenerative Diseases in the CNS
por: Kimura, Kimitoshi, et al.
Publicado: (2023)

Up-Regulation of miRNA-146a in Progressive, Age-Related Inflammatory Neurodegenerative Disorders of the Human CNS
por: Alexandrov, Peter N., et al.
Publicado: (2014)

Hornet Sting
por: Finlayson, Walter J.
Publicado: (1908)

Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease
por: Chastain, Emily M. L., et al.
Publicado: (2012)

Brief Electrical Stimulation Triggers an Effective Regeneration of Leech CNS
por: Cohen, Sharon, et al.
Publicado: (2020)

STING: infection, inflammation and cancer
por: Barber, Glen N.
Publicado: (2015)

STING Signaling and Sterile Inflammation
por: Couillin, Isabelle, et al.
Publicado: (2021)

Sting /
por: Leduc, Jean-Marie
Publicado: (1992)

The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases
por: Correia, Susana S., et al.
Publicado: (2021)

Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis
por: Chen, Yuhong, et al.
Publicado: (2023)

Protocol for Monitoring DNA-Triggered cGAS/STING Signaling in Mammalian Cells and Mice
por: Wang, Ying, et al.
Publicado: (2020)

Treatment of Scorpion Stings
por: Pancholy, K. J.
Publicado: (1936)

C9orf72 in myeloid cells suppresses STING-induced inflammation
por: McCauley, Madelyn E., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g0kad34qt2gj1ju4ev8o6agam3