Distinct Effects of Familial Parkinson’s Disease-Associated Mutations on α-Synuclein Phase Separation and Amyloid Aggregation

The Lewy bodies and Lewy neurites are key pathological hallmarks of Parkinson’s disease (PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) aggregation, leading to the formation of Lewy bodies and Lewy neurites. Recent studies suggest α-Syn nucleates through liquid–liq...

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Detalles Bibliográficos
Autores principales: Xu, Bingkuan, Fan, Fengshuo, Liu, Yunpeng, Liu, Yinghui, Zhou, Lin, Yu, Haijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216457/
https://www.ncbi.nlm.nih.gov/pubmed/37238596
http://dx.doi.org/10.3390/biom13050726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216457/
https://www.ncbi.nlm.nih.gov/pubmed/37238596
http://dx.doi.org/10.3390/biom13050726

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