Development of a Non-Peptide Angiotensin II Type 1 Receptor Ligand by Structural Modification of Olmesartan as a Biased Agonist

As a biased agonist, peptide angiotensin II (Ang II) type 1 (AT(1)) receptor ligand antagonizes Ang II-stimulated G protein signaling but stimulates several kinase pathways. Here, we developed a non-peptide AT(1) receptor compound as a biased ligand. We synthesized three non-peptide AT(1) receptor l...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsuo, Yoshino, Suematsu, Yasunori, Morita, Hidetaka, Miura, Shin-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216478/
https://www.ncbi.nlm.nih.gov/pubmed/37239156
http://dx.doi.org/10.3390/biomedicines11051486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216478/
https://www.ncbi.nlm.nih.gov/pubmed/37239156
http://dx.doi.org/10.3390/biomedicines11051486

Ejemplares similares