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Development of a Non-Peptide Angiotensin II Type 1 Receptor Ligand by Structural Modification of Olmesartan as a Biased Agonist
As a biased agonist, peptide angiotensin II (Ang II) type 1 (AT(1)) receptor ligand antagonizes Ang II-stimulated G protein signaling but stimulates several kinase pathways. Here, we developed a non-peptide AT(1) receptor compound as a biased ligand. We synthesized three non-peptide AT(1) receptor l...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216478/ https://www.ncbi.nlm.nih.gov/pubmed/37239156 http://dx.doi.org/10.3390/biomedicines11051486 |