Evaluation of the Elements of Short Hairpin RNAs in Developing shRNA-Containing CAR T Cells

SIMPLE SUMMARY: Knocking down genes by shRNAs in CAR T cells offers the potential of expanding the therapy’s efficacy beyond its initial success. Since shRNAs are in the CAR construct, only the CAR specifically will be affected by the knockdown. Due to that intrinsic nature, we show that these knock...

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Detalles Bibliográficos
Autores principales: Urak, Ryan, Gittins, Brenna, Soemardy, Citradewi, Grepo, Nicole, Goldberg, Lior, Maker, Madeleine, Shevchenko, Galina, Davis, Alicia, Li, Shirley, Scott, Tristan, Morris, Kevin V., Forman, Stephen J., Wang, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216594/
https://www.ncbi.nlm.nih.gov/pubmed/37345185
http://dx.doi.org/10.3390/cancers15102848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216594/
https://www.ncbi.nlm.nih.gov/pubmed/37345185
http://dx.doi.org/10.3390/cancers15102848

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