DNA Methyltransferase 1 Targeting Using Guadecitabine Inhibits Prostate Cancer Growth by an Apoptosis-Independent Pathway

SIMPLE SUMMARY: We describe the unique role of guadecitabine (gDEC) activating lysine methyltransferases (KMTs) in association with prostate cancer inhibition. This study suggests that one consequence of DNMT1-targeting by gDEC is the upregulation of epigenetic activating enzymes to contribute to th...

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Detalles Bibliográficos
Autores principales: Karan, Dev, Singh, Manohar, Dubey, Seema, Van Veldhuizen, Peter J., Saunthararajah, Yogen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216613/
https://www.ncbi.nlm.nih.gov/pubmed/37345101
http://dx.doi.org/10.3390/cancers15102763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216613/
https://www.ncbi.nlm.nih.gov/pubmed/37345101
http://dx.doi.org/10.3390/cancers15102763

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