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DNA Methyltransferase 1 Targeting Using Guadecitabine Inhibits Prostate Cancer Growth by an Apoptosis-Independent Pathway

SIMPLE SUMMARY: We describe the unique role of guadecitabine (gDEC) activating lysine methyltransferases (KMTs) in association with prostate cancer inhibition. This study suggests that one consequence of DNMT1-targeting by gDEC is the upregulation of epigenetic activating enzymes to contribute to th...

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Detalles Bibliográficos
Autores principales:	Karan, Dev, Singh, Manohar, Dubey, Seema, Van Veldhuizen, Peter J., Saunthararajah, Yogen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216613/ https://www.ncbi.nlm.nih.gov/pubmed/37345101 http://dx.doi.org/10.3390/cancers15102763

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