Structural Changes, Biological Consequences, and Repurposing of Colchicine Site Ligands

Microtubule-targeting agents (MTAs) bind to one of several distinct sites in the tubulin dimer, the subunit of microtubules. The binding affinities of MTAs may vary by several orders of magnitude, even for MTAs that specifically bind to a particular site. The first drug binding site discovered in tu...

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Detalles Bibliográficos
Autores principales: Montecinos, Felipe, Sackett, Dan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216767/
https://www.ncbi.nlm.nih.gov/pubmed/37238704
http://dx.doi.org/10.3390/biom13050834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216767/
https://www.ncbi.nlm.nih.gov/pubmed/37238704
http://dx.doi.org/10.3390/biom13050834

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