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Structural Changes, Biological Consequences, and Repurposing of Colchicine Site Ligands
Microtubule-targeting agents (MTAs) bind to one of several distinct sites in the tubulin dimer, the subunit of microtubules. The binding affinities of MTAs may vary by several orders of magnitude, even for MTAs that specifically bind to a particular site. The first drug binding site discovered in tu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216767/ https://www.ncbi.nlm.nih.gov/pubmed/37238704 http://dx.doi.org/10.3390/biom13050834 |