Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach

SIMPLE SUMMARY: Blocking telomerase to drive telomere erosion-dependent antiproliferative effects in cancer cells appears impractical. However, the evidence of extra-telomeric functions of TERT, the catalytic component of telomerase, in promoting tumour growth/progression strongly supports the poten...

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Detalles Bibliográficos
Autores principales: Amin, Aamir, Morello, Marzia, Petrara, Maria Raffaella, Rizzo, Beatrice, Argenton, Francesco, De Rossi, Anita, Giunco, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216832/
https://www.ncbi.nlm.nih.gov/pubmed/37345011
http://dx.doi.org/10.3390/cancers15102673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216832/
https://www.ncbi.nlm.nih.gov/pubmed/37345011
http://dx.doi.org/10.3390/cancers15102673

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