The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G(2)-Checkpoint Activation in Cells Exposed to Ionizing Radiation

We have recently reported that in G(2)-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G(2)-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle through Chk1. However, although inhibition of ATR ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Daxian, Mladenov, Emil, Soni, Aashish, Stuschke, Martin, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216922/
https://www.ncbi.nlm.nih.gov/pubmed/37408221
http://dx.doi.org/10.3390/cells12101387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216922/
https://www.ncbi.nlm.nih.gov/pubmed/37408221
http://dx.doi.org/10.3390/cells12101387

Ejemplares similares