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The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G(2)-Checkpoint Activation in Cells Exposed to Ionizing Radiation
We have recently reported that in G(2)-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G(2)-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle through Chk1. However, although inhibition of ATR ne...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216922/ https://www.ncbi.nlm.nih.gov/pubmed/37408221 http://dx.doi.org/10.3390/cells12101387 |