Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor prognosis. Gemcitabine is the first-line therapy for PDAC, but gemcitabine resistance is a major impediment to achieving satisfactory clinical outcomes. This study investigated whether methylglyoxal (MG), an oncometabolite spontane...

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Detalles Bibliográficos
Autores principales: Crake, Rebekah, Gasmi, Imène, Dehaye, Jordan, Lardinois, Fanny, Peiffer, Raphaël, Maloujahmoum, Naïma, Agirman, Ferman, Koopmansch, Benjamin, D’Haene, Nicky, Azurmendi Senar, Oier, Arsenijevic, Tatjana, Lambert, Frédéric, Peulen, Olivier, Van Laethem, Jean-Luc, Bellahcène, Akeila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217245/
https://www.ncbi.nlm.nih.gov/pubmed/37408249
http://dx.doi.org/10.3390/cells12101414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217245/
https://www.ncbi.nlm.nih.gov/pubmed/37408249
http://dx.doi.org/10.3390/cells12101414

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