Cargando…

Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor prognosis. Gemcitabine is the first-line therapy for PDAC, but gemcitabine resistance is a major impediment to achieving satisfactory clinical outcomes. This study investigated whether methylglyoxal (MG), an oncometabolite spontane...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crake, Rebekah, Gasmi, Imène, Dehaye, Jordan, Lardinois, Fanny, Peiffer, Raphaël, Maloujahmoum, Naïma, Agirman, Ferman, Koopmansch, Benjamin, D’Haene, Nicky, Azurmendi Senar, Oier, Arsenijevic, Tatjana, Lambert, Frédéric, Peulen, Olivier, Van Laethem, Jean-Luc, Bellahcène, Akeila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217245/ https://www.ncbi.nlm.nih.gov/pubmed/37408249 http://dx.doi.org/10.3390/cells12101414

Ejemplares similares

Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
por: Rademaker, Gilles, et al.
Publicado: (2019)

Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells
por: Anania, Sandy, et al.
Publicado: (2020)

Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination
por: Rademaker, Gilles, et al.
Publicado: (2022)

Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
por: Rademaker, Gilles, et al.
Publicado: (2023)

Methylglyoxal: a novel upstream regulator of DNA methylation
por: Dube, Gaurav, et al.
Publicado: (2023)

Myoferlin Contributes to the Metastatic Phenotype of Pancreatic Cancer Cells by Enhancing Their Migratory Capacity through the Control of Oxidative Phosphorylation
por: Rademaker, Gilles, et al.
Publicado: (2019)

Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells
por: Rademaker, Gilles, et al.
Publicado: (2022)

Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer
por: Peiffer, Raphaël, et al.
Publicado: (2022)

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death
por: Nokin, Marie-Julie, et al.
Publicado: (2017)

Pancreatic Cancer Meets Human Microbiota: Close Encounters of the Third Kind
por: Arsenijevic, Tatjana, et al.
Publicado: (2021)

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes
por: Chiavarina, Barbara, et al.
Publicado: (2014)

Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer
por: Chiavarina, Barbara, et al.
Publicado: (2017)

Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile
por: Koopmansch, Caroline, et al.
Publicado: (2019)

Ferlin Overview: From Membrane to Cancer Biology
por: Peulen, Olivier, et al.
Publicado: (2019)

Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer
por: Nokin, Marie-Julie, et al.
Publicado: (2019)

The Prognostic Value of the Combination of Low VEGFR-1 and High VEGFR-2 Expression in Endothelial Cells of Colorectal Cancer
por: D’Haene, Nicky, et al.
Publicado: (2018)

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis
por: Nokin, Marie-Julie, et al.
Publicado: (2016)

Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV
por: Catteau, Xavier, et al.
Publicado: (2020)

PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium
por: Bienfait, Lucie, et al.
Publicado: (2018)

Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report
por: Catteau, Xavier, et al.
Publicado: (2021)

First Report on Fetal Cerebral Polyglucosan Bodies in Mucopolysaccharidosis Type VII
por: Kadhim, Hazim, et al.
Publicado: (2017)

P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma
por: Bouri, Sarah, et al.
Publicado: (2020)

Invasive ductal carcinoma arising in borderline phyllode tumor: A potential role of PIK3CA mutation
por: Bouri, Sarah, et al.
Publicado: (2020)

First Case Report of a Uterine Angiolipoleiomyoma With KRAS and KIT Mutations
por: Verocq, Camille, et al.
Publicado: (2022)

Clinical Application of Targeted Next Generation Sequencing for Colorectal Cancers
por: Fontanges, Quitterie, et al.
Publicado: (2016)

Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes
por: Blomme, Arnaud, et al.
Publicado: (2016)

Interpreting the impact of noncoding structural variation in neurodevelopmental disorders
por: D’haene, Eva, et al.
Publicado: (2020)

Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence
por: Luis, Géraldine, et al.
Publicado: (2021)

SMAD4 Positive Pancreatic Ductal Adenocarcinomas Are Associated with Better Outcomes in Patients Receiving FOLFIRINOX-Based Neoadjuvant Therapy
por: Racu, Marie-Lucie, et al.
Publicado: (2023)

Borderline phyllodes tumour of the breast with eosinophilic inclusion bodies: Case report and molecular sequencing
por: Lam, Ngoc My, et al.
Publicado: (2023)

Changes in the transcriptional profile in response to overexpression of the osteopontin-c splice isoform in ovarian (OvCar-3) and prostate (PC-3) cancer cell lines
por: Tilli, Tatiana M, et al.
Publicado: (2014)

Fasting, food and farming: Value chains and food taboos in Ethiopia
por: D’Haene, Eline, et al.
Publicado: (2021)

Design and Validation of a Gene-Targeted, Next-Generation Sequencing Panel for Routine Diagnosis in Gliomas
por: D’Haene, Nicky, et al.
Publicado: (2019)

Innovative methodology for the identification of soluble biomarkers in fresh tissues
por: Costanza, Brunella, et al.
Publicado: (2018)

Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness
por: Rademaker, Gilles, et al.
Publicado: (2018)

Pancreatic medullary carcinoma developed on a pancreatic intraductal papillary mucinous neoplasm with loss of MSH2 and MSH6 expression: a case report
por: Verocq, Camille, et al.
Publicado: (2021)

VEGFR1 and VEGFR2 Involvement in Extracellular Galectin-1- and Galectin-3-Induced Angiogenesis
por: D'Haene, Nicky, et al.
Publicado: (2013)

Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen-Glucose Deprivation
por: Chen, Wei, et al.
Publicado: (2022)

Mimicking and anticipating others’ actions is linked to Social Information Processing
por: Genschow, Oliver, et al.
Publicado: (2018)

KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature
por: Bouri, Sarah, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_48hgiv4ievue9kfsmdrs7ru4bf