Cargando…

Numerical Optimization of Prednisolone–Tacrolimus Loaded Ultraflexible Transethosomes for Transdermal Delivery Enhancement; Box–Behnken Design, Evaluation, Optimization, and Pharmacokinetic Study

The aim of the present study is to formulate highly permeable carriers (i.e., transethosomes) for enhancing the delivery of prednisolone combined with tacrolimus for both topical and systemic pathological conditions. A Box–Behnken experimental design was implemented in this research. Three independe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alfadhel, Munerah M., Zaki, Randa Mohammed, Aldosari, Basmah Nasser, Sayed, Ossama M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217343/ https://www.ncbi.nlm.nih.gov/pubmed/37232992 http://dx.doi.org/10.3390/gels9050400

Ejemplares similares

Formulation Development, Optimization by Box–Behnken Design, and In Vitro and Ex Vivo Characterization of Hexatriacontane-Loaded Transethosomal Gel for Antimicrobial Treatment for Skin Infections
por: Aodah, Alhussain H., et al.
Publicado: (2023)

Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cell lines
por: Zaki, Randa Mohammed, et al.
Publicado: (2023)

Preparation and Optimization of an Ultraflexible Liposomal Gel for Lidocaine Transdermal Delivery
por: Sun, Mengwei, et al.
Publicado: (2022)

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery
por: Sguizzato, Maddalena, et al.
Publicado: (2021)

Wound Healing Efficacy of Rosuvastatin Transethosomal Gel, I Optimal Optimization, Histological and In Vivo Evaluation
por: Zaki, Randa Mohammed, et al.
Publicado: (2022)

Tioconazole-Loaded Transethosomal Gel Using Box–Behnken Design for Topical Applications: In Vitro, In Vivo, and Molecular Docking Approaches
por: Qureshi, Muhammad Imran, et al.
Publicado: (2023)

Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation
por: Abdulbaqi, Ibrahim M, et al.
Publicado: (2018)

Transethosomal Gel for the Topical Delivery of Celecoxib: Formulation and Estimation of Skin Cancer Progression
por: Abdellatif, Ahmed A. H., et al.
Publicado: (2022)

The application of Box-Behnken-Design in the optimization of HPLC separation of fluoroquinolones
por: Czyrski, Andrzej, et al.
Publicado: (2019)

Synthesis of Polyhydroxyurethanes—Experimental Verification of the Box–Behnken Optimization Model
por: Zalewski, Michał J., et al.
Publicado: (2022)

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System
por: Sudhakar, Kalvatala, et al.
Publicado: (2021)

Optimization of the Poly(glycerol citraconate) Synthesis Using the Box–Behnken Design
por: Kolankowski, Krzysztof, et al.
Publicado: (2023)

Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design
por: Hashemi, Mahbubeh, et al.
Publicado: (2017)

Ginger Extract–Loaded Transethosomes for Effective Transdermal Permeation and Anti-Inflammation in Rat Model
por: Hassan, Abeer S, et al.
Publicado: (2023)

SPME Method Optimized by Box-Behnken Design for Impact Odorants in Reduced Alcohol Wines
por: Saha, Bithika, et al.
Publicado: (2018)

Formulation Optimization and Assessment of Dexamethasone Orally Disintegrating Tablets Using Box-Behnken Design
por: Soroush, Hadis, et al.
Publicado: (2018)

Box–Behnken Design: Optimization of Proanthocyanidin-Loaded Transferosomes as an Effective Therapeutic Approach for Osteoarthritis
por: Tamilarasan, Neelakandan, et al.
Publicado: (2022)

Pomegranate Flower Extract—The Health-Promoting Properties Optimized by Application of the Box–Behnken Design
por: Gościniak, Anna, et al.
Publicado: (2022)

Optimizing Catalytic Depolymerization of Lignin in Ethanol with a Day-Clustered Box–Behnken Design
por: Kouris, Panos D., et al.
Publicado: (2023)

Evaluation and Multi-Objective Optimization of Lightweight Mortars Parameters at Elevated Temperature via Box–Behnken Optimization Approach
por: Kaya, Mehmet, et al.
Publicado: (2021)

Brain Targeting of Quetiapine Fumarate via Intranasal Delivery of Loaded Lipospheres: Fabrication, In-Vitro Evaluation, Optimization, and In-Vivo Assessment
por: Zaki, Randa Mohammed, et al.
Publicado: (2022)

Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation
por: Albash, Rofida, et al.
Publicado: (2019)

Application of Response Surface Methodology and Box–Behnken Design for the Optimization of the Stability of Fibrous Dispersion Used in Drilling and Completion Operations
por: Alhajabdalla, Mohammed, et al.
Publicado: (2021)

Mercerization Optimization of Bamboo (Bambusa vulgaris) Fiber-Reinforced Epoxy Composite Structures Using a Box–Behnken Design
por: Hassan, Mohamad Zaki, et al.
Publicado: (2020)

Formulation and optimization of itraconazole polymeric lipid hybrid nanoparticles (Lipomer) using box behnken design
por: Gajra, Balaram, et al.
Publicado: (2015)

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy
por: Anicescu, Maria-Cristina, et al.
Publicado: (2022)

Development and Optimization of Ciprofloxacin HCl-Loaded Chitosan Nanoparticles Using Box–Behnken Experimental Design
por: Soliman, Noha M., et al.
Publicado: (2022)

Optimization of Nasal Liposome Formulation of Venlafaxine Hydrochloride using a Box-Behnken Experimental Design
por: Khute, Sulekha, et al.
Publicado: (2023)

Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity against H-1975 Cell Lines
por: Zaki, Randa Mohammed, et al.
Publicado: (2022)

Box–Behnken Design for Polycarbonate-Pigment Blending: Applications and Characterization Techniques
por: Alsadi, Jamal, et al.
Publicado: (2022)

Development and Optimization of Erythromycin Loaded Transethosomes Cinnamon Oil Based Emulgel for Antimicrobial Efficiency
por: Abdallah, Marwa H., et al.
Publicado: (2023)

Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity
por: Nasr, Ali M., et al.
Publicado: (2023)

Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate
por: Zaki, Randa Mohammed, et al.
Publicado: (2022)

Development and statistical optimization of nefopam hydrochloride loaded nanospheres for neuropathic pain using Box–Behnken design
por: Sukhbir, S., et al.
Publicado: (2016)

Optimization of Chitosan–Alginate Microparticles for Delivery of Mangostins to the Colon Area Using Box–Behnken Experimental Design
por: Mulia, Kamarza, et al.
Publicado: (2020)

Preparation, Statistical Optimization and Characterization of Propolis-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design
por: Taherzadeh, Sahar, et al.
Publicado: (2021)

Supercritical carbon dioxide extraction of Usnea longissima (L.) Ach.: Optimization by Box-Behnken design (BBD)
por: ATİLA DİNÇER, Ceren, et al.
Publicado: (2021)

Optimization of the Sound Absorption Coefficient (SAC) from Cellulose–Silica Aerogel Using the Box–Behnken Design
por: Silviana, S., et al.
Publicado: (2022)

Formulation and Characterization of Ursodeoxycholic Acid Nanosuspension Based on Bottom-Up Technology and Box–Behnken Design Optimization
por: Boscolo, Oriana, et al.
Publicado: (2023)

Optimization of process parameters for trimethoprim and sulfamethoxazole removal by magnetite-chitosan nanoparticles using Box–Behnken design
por: Alishiri, Mahsa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2ml0lirmsutopf2ki95ejfo9nb