Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment

As unicellular parasites are highly dependent on NADPH as a source for reducing equivalents, the main NADPH-producing enzymes glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) of the pentose phosphate pathway are considered promising antitrypanosomatid drug targets...

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Detalles Bibliográficos
Autores principales: Berneburg, Isabell, Stumpf, Michaela, Velten, Ann-Sophie, Rahlfs, Stefan, Przyborski, Jude, Becker, Katja, Fritz-Wolf, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217883/
https://www.ncbi.nlm.nih.gov/pubmed/37239962
http://dx.doi.org/10.3390/ijms24108615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217883/
https://www.ncbi.nlm.nih.gov/pubmed/37239962
http://dx.doi.org/10.3390/ijms24108615

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